MAME 0.163 Roms

MAME 0.163 Roms
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Data were found for 22 substrates, 30 interacting drugs, and 38 substrate-interacting drug couples.

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It relies on in vivo data and uses the following three characteristic parameters: one for the victim drug, one for the interacting drug, and another for the genotype.. The metrics of interest are the ratio of victim drug area under the curve (AUC) in patients with genetic variants taking both drugs, to the AUC in patients with either variant or wild-type genotype taking the victim drug alone.. Grabit 4 919 These parameters are known for a wide range of drugs and genotypes.. The approach was evaluated by external validation, comparing predicted and observed AUC ratios found in the literature.

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